POS1045 HISTOLOGICAL COMPOSITION OF (TENO)SYNOVIAL AND SYNOVIAL INFLAMMATION IN RHEUMATOID ARTHRITIS ACROSS DISEASE PHASES
نویسندگان
چکیده
Background Subclinical tenosynovitis arose as a primary sign of inflammation already in the pre-clinical phases Rheumatoid Arthritis (RA) and is common feature active state might persist although sustained remission achieved. Objectives To assess histological features (teno)synovium from extensor digitorum tendons hand across RA trajectory to compare it with paired synovial tissue samples. Methods Thirty-seven patients underwent minimally invasive ultrasound (US)-guided biopsy tenosynovium [n=16 clinically suspected arthralgia (CSA), n=19 (n=4 naïve, n=6 resistant csDMARDS, n=8 bDMARDs, n=1 respectively)]. Twenty-three out 37 presenting CSA or evident synovitis peripheral joint (whether anatomically adjacent not tendon interest) US-guided (ST) also that location. The Krenn score (KSS) inflammatory infiltrate using CD68/CD21/CD3/CD20 immunohistochemical (IHC) analysis were assessed for each sample. Results Tenosynovium belonging compartment wrist was successfully collected technique enabled retrieve representative samples terms lining sublining layers presence 86.5% 100% cases, respectively. Considering pre-arthritis subgroup, KSS similar ACPA/RF pos vs neg (p=0.5814) contingent activity, being significantly higher naïve (ANOVA p<0.001) compared CSA. Moreover, comparison between (teno)synovial two anatomical locations revealed value (p>0.999) IHC showed comparable enrichment CD68 , CD20 CD3 cells (for all comparisons p>0.05) sites, naive c- b-DMARDs patients. procedure well tolerated, no injury occurred within 10 months follow-up. One patient developed local hematoma recovered after topic treatment. Conclusion (Teno)synovium retrievable through its directly related disease state. Semiquantitative degree cellular composition sites same person. REFERENCES: NIL. Acknowledgements: Disclosure Interests None Declared.
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2023
ISSN: ['1468-2060', '0003-4967']
DOI: https://doi.org/10.1136/annrheumdis-2023-eular.4752